World Library  


Add to Book Shelf
Flag as Inappropriate
Email this Book

Plos One : Survival of Cancer Stem Cells Under Hypoxia and Serum Depletion Via Decrease in Pp2A Activity and Activation of P38-mapkapk2-hsp27, Volume 7

By Koritzinsky, Marianne

Click here to view

Book Id: WPLBN0003960487
Format Type: PDF eBook :
File Size:
Reproduction Date: 2015

Title: Plos One : Survival of Cancer Stem Cells Under Hypoxia and Serum Depletion Via Decrease in Pp2A Activity and Activation of P38-mapkapk2-hsp27, Volume 7  
Author: Koritzinsky, Marianne
Volume: Volume 7
Language: English
Subject: Journals, Science, Medical Science
Collections: Periodicals: Journal and Magazine Collection (Contemporary)
Historic
Publication Date:
Publisher: Plos

Citation

APA MLA Chicago

Koritzinsky, M. (n.d.). Plos One : Survival of Cancer Stem Cells Under Hypoxia and Serum Depletion Via Decrease in Pp2A Activity and Activation of P38-mapkapk2-hsp27, Volume 7. Retrieved from http://www.nationalpubliclibrary.info/


Description
Description : Hypoxia and serum depletion are common features of solid tumors that occur upon antiangiogenesis, irradiation and chemotherapy across a wide variety of malignancies. Here we show that tumor cells expressing CD133, a marker for colorectal cancer initiating or stem cells, are enriched and survive under hypoxia and serum depletion conditions, whereas CD1332 cells undergo apoptosis. CD133+ tumor cells increase cancer stem cell and epithelial-mesenchymal transition properties. Moreover, via screening a panel of tyrosine and serine/threonine kinase pathways, we identified Hsp27 is constitutively activated in CD133+ cells rather than CD1332 cell under hypoxia and serum depletion conditions. However, there was no difference in Hsp27 activation between CD133+ and CD1332 cells under normal growth condition. Hsp27 activation, which was mediated by the p38MAPK-MAPKAPK2-Hsp27 pathway, is required for CD133+ cells to inhibit caspase 9 and 3 cleavage. In addition, inhibition of Hsp27 signaling sensitizes CD133+ cells to hypoxia and serum depletion -induced apoptosis. Moreover, the antiapoptotic pathway is also activated in spheroid culture-enriched CD133+ cancer stem cells from a variety of solid tumor cells including lung, brain and oral cancer, suggesting it is a common pathway activated in cancer stem cells from multiple tumor types. Thus, activation of PP2A or inactivation of the p38MAPK-MAPKAPK2-Hsp27 pathway may develop new strategies for cancer therapy by suppression of their TIC population.

 

Click To View

Additional Books


  • Plos One : Difficulties in Generating Sp... (by )
  • Plos One : Interaction of Multimicrobial... (by )
  • Plos One : the Light Chains of Microtubu... (by )
  • Plos One : Vav1 Fine Tunes P53 Control o... (by )
  • Plos One : Numerical Study of Boundary L... (by )
  • Plos One : Spontaneous Abortion and a Di... (by )
  • Plos One : a Pilot Study to Examine the ... (by )
  • Plos One : Revisiting the Effect of Capt... (by )
  • Plos One : Msl2 is a Novel Component of ... (by )
  • Plos One : Metastability and Inter-band ... (by )
  • Plos One : High Cytoplasmic Foxo1 and Pf... (by )
  • Plos One : Calpain, Volume 7 (by )
Scroll Left
Scroll Right

 



Copyright © World Library Foundation. All rights reserved. eBooks from National Public Library are sponsored by the World Library Foundation,
a 501c(4) Member's Support Non-Profit Organization, and is NOT affiliated with any governmental agency or department.