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Plos One : Statistical Assessment of Crosstalk Enrichment Between Gene Groups in Biological Networks, Volume 7

By Ouzounis, Christos, A.

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Book Id: WPLBN0003960293
Format Type: PDF eBook :
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Reproduction Date: 2015

Title: Plos One : Statistical Assessment of Crosstalk Enrichment Between Gene Groups in Biological Networks, Volume 7  
Author: Ouzounis, Christos, A.
Volume: Volume 7
Language: English
Subject: Journals, Science, Medical Science
Collections: Periodicals: Journal and Magazine Collection (Contemporary)
Historic
Publication Date:
Publisher: Plos

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Ouzounis, C. A. (n.d.). Plos One : Statistical Assessment of Crosstalk Enrichment Between Gene Groups in Biological Networks, Volume 7. Retrieved from http://www.nationalpubliclibrary.info/


Description
Description : Here we present CrossTalkZ, a statistical method and software to assess the significance of crosstalk enrichment between pairs of gene or protein groups in large biological networks. We demonstrate that the standard z-score is generally an appropriate and unbiased statistic. We further evaluate the ability of four different methods to reliably recover crosstalk within known biological pathways. We conclude that the methods preserving the second-order topological network properties perform best. Finally, we show how CrossTalkZ can be used to annotate experimental gene sets using known pathway annotations and that its performance at this task is superior to gene enrichment analysis (GEA).

 

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