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Plos One : Dengue in Travelers ; Kinetics of Viremia and Ns1 Antigenemia and Their Associations with Clinical Parameters, Volume 8

By Ooi, Eng, Eong

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Book Id: WPLBN0003946376
Format Type: PDF eBook :
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Reproduction Date: 2015

Title: Plos One : Dengue in Travelers ; Kinetics of Viremia and Ns1 Antigenemia and Their Associations with Clinical Parameters, Volume 8  
Author: Ooi, Eng, Eong
Volume: Volume 8
Language: English
Subject: Journals, Science, Medical Science
Collections: Periodicals: Journal and Magazine Collection (Contemporary)
Historic
Publication Date:
Publisher: Plos

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Ooi, E. E. (n.d.). Plos One : Dengue in Travelers ; Kinetics of Viremia and Ns1 Antigenemia and Their Associations with Clinical Parameters, Volume 8. Retrieved from http://www.nationalpubliclibrary.info/


Description
Description : Despite the increasing numbers of travel-acquired dengue, few studies have assessed virologic markers of the disease in non-endemic populations. We examined the kinetics of diagnostic markers and their associations with clinical parameters in 93 patients with travel-acquired dengue fever. Kinetics analyses suggested a longer average duration for viremia (9 days, CI95% : 8–10) and non-structural protein 1 (NS1) antigenemia (15 days, CI95% : 12–20) than reported in endemic populations. While none of the tests sufficed alone, the best diagnostic coverage was achieved by combining antibody detection with RNA or NS1 testing. Studied by regression models, early relative levels of viremia and NS1 antigenemia proved to be significantly associated with several clinical parameters : high viremia predicted greater likelihood and increased length of hospitalization, the degree of NS1 antigenemia correlated positively with hematocrit and liver transaminases, and both viremia and NS1 antigenemia levels negatively with platelet counts in follow-up. Levels of viremia and NS1 antigenemia may serve as predictors of the clinical manifestations in travel-acquired dengue.

 

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