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Plos One : Induction of Hca587-specific Antitumor Immunity with Hca587 Protein Formulated with Cpg and Iscom in Mice, Volume 7

By Rodrigues, Mauricio Martins

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Book Id: WPLBN0003939458
Format Type: PDF eBook :
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Reproduction Date: 2015

Title: Plos One : Induction of Hca587-specific Antitumor Immunity with Hca587 Protein Formulated with Cpg and Iscom in Mice, Volume 7  
Author: Rodrigues, Mauricio Martins
Volume: Volume 7
Language: English
Subject: Journals, Science, Medical Science
Collections: Periodicals: Journal and Magazine Collection (Contemporary)
Historic
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Publisher: Plos

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Rodrigues, M. M. (n.d.). Plos One : Induction of Hca587-specific Antitumor Immunity with Hca587 Protein Formulated with Cpg and Iscom in Mice, Volume 7. Retrieved from http://www.nationalpubliclibrary.info/


Description
Description : HCA587 (also known as MAGE-C2) is a ‘‘cancer-testis’’ antigen highly expressed in a number of malignancies with unique immunological properties, making it a promising target for tumor immunotherapy. In this report, we demonstrated that HCA587 protein, when formulated with adjuvants CpG–containing oligodeoxynucleotides (CpG ODN) and ISCOM, was capable of inducing a potent cellular and humoral immune response as indicated by the presence of a large number of HCA587-specific, IFN-c-producing CD4+ T cells and high levels of HCA587-specific antibodies. More importantly, vaccination with HCA587 conferred protection against challenge with HCA587-expressing B16 melanoma in prophylactic and therapeutic settings. In analysis of the mechanisms underlying the protective effect, we showed that the vaccination was followed by enhanced accumulation of tumor-infiltrating lymphocytes (TILs) with enrichment of conventional CD4+ T cells but reduced representation of Treg cells. Further, the antitumor effect was largely abrogated in mice either depleted of CD4+ T cells or deficient for IFN-c. These results indicate that HCA587 protein vaccine possesses evident antitumor activity in a mouse model and holds promise for treatment of human cancers.

 

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