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Plos Computational Biology : the Rna Silencing Pathway ; the Bits and Pieces That Matter, Volume 1

By Levin, Simon

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Book Id: WPLBN0003922044
Format Type: PDF eBook :
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Reproduction Date: 2015

Title: Plos Computational Biology : the Rna Silencing Pathway ; the Bits and Pieces That Matter, Volume 1  
Author: Levin, Simon
Volume: Volume 1
Language: English
Subject: Journals, Science, Computational Biology
Collections: Periodicals: Journal and Magazine Collection, PLoS Computational Biology
Historic
Publication Date:
Publisher: Plos

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Levin, S. (n.d.). Plos Computational Biology : the Rna Silencing Pathway ; the Bits and Pieces That Matter, Volume 1. Retrieved from http://www.nationalpubliclibrary.info/


Description
Description : Cellular pathways are generally proposed on the basis of available experimental knowledge. The proposed pathways, however, may be inadequate to describe the phenomena they are supposed to explain. For instance, by means of concise mathematical models we are able to reveal shortcomings in the current description of the pathway of RNA silencing. The silencing pathway operates by cleaving siRNAs from dsRNA. siRNAs can associate with RISC, leading to the degradation of the target mRNA. We propose and analyze a few small extensions to the pathway : a siRNA degrading RNase, primed amplification of aberrant RNA pieces, and cooperation between aberrant RNA to trigger amplification. These extensions allow for a consistent explanation for various types of silencing phenomena, such as virus induced silencing, transgene and transposon induced silencing, and avoidance of self-reactivity, as well as for differences found between species groups.

 

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