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Plos One : a Spiroligomer Α-helix Mimic That Binds Hdm2, Penetrate...

By: Giorgio Colombo

Description : We demonstrate functionalized spiroligomers that mimic the HDM2-bound conformation of the p53 activation domain. Spiroligomers are stereochemically defined, functionalized, spirocyclic monomers coupled through pairs of amide bonds to create spiro-ladder oligomers [1]. Two series of spiroligomers were synthesized, one of structural analogs and one of stereochemical analogs, from which we identified compound 1, that binds HDM2 with a Kd value of 400 nM. The s...

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Plos One : Recruiting at the Edge ; Kinetic Energy Inhibits Anchov...

By: Konstantinos I. Stergiou

Description : The Strait of Gibraltar replenishes the Mediterranean with Atlantic waters through an intense eastward current known as the Atlantic Jet (AJ). The AJ fertilizes the southwestern Mediterranean and is considered to be the ultimate factor responsible for the comparatively high fish production of this region. Here, we perform an analysis of the available historical catches and catch per unit effort (CPUE), together with a long series of surface currents, kineti...

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Plos One : Induction of Hca587-specific Antitumor Immunity with Hc...

By: Mauricio Martins Rodrigues

Description : HCA587 (also known as MAGE-C2) is a ‘‘cancer-testis’’ antigen highly expressed in a number of malignancies with unique immunological properties, making it a promising target for tumor immunotherapy. In this report, we demonstrated that HCA587 protein, when formulated with adjuvants CpG–containing oligodeoxynucleotides (CpG ODN) and ISCOM, was capable of inducing a potent cellular and humoral immune response as indicated by the presence of a large number of ...

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Plos One : Insights Into the N-sulfation Mechanism ; Molecular Dyn...

By: Emily Parker

Description : Sulfation patterns along glycosaminoglycan (GAG) chains dictate their functional role. The N-deacetylase N-sulfotransferase family (NDST) catalyzes the initial downstream modification of heparan sulfate and heparin chains by removing acetyl groups from subsets of N-acetylglucosamine units and, subsequently, sulfating the residual free amino groups. These enzymes transfer the sulfuryl group from 39-phosphoadenosine-59-phosphosulfate (PAPS), yielding sulfated...

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Plos One : Delphinidin-3-glucoside Protects Against Oxidized Low- ...

By: Gabriele Vincenzo Gnoni

Description : Delphinidin-3-glucoside (Dp) is a member of a family of bioactive compounds known as anthocyanins that occur naturally in pigmented plants and are known to ameliorate oxidative stress. Previous studies have showed that Dp decreased oxidative stress in vascular endothelial cells, however, the underlying mechanisms remain largely unknown. In the present study, we showed that pretreatment with Dp significantly suppressed oxidized low-density lipoprotein (oxLDL...

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Plos One : Leukemia Prediction Using Sparse Logistic Regression, V...

By: Robert K. Hills

Description : We describe a supervised prediction method for diagnosis of acute myeloid leukemia (AML) from patient samples based on flow cytometry measurements. We use a data driven approach with machine learning methods to train a computational model that takes in flow cytometry measurements from a single patient and gives a confidence score of the patient being AML-positive. Our solution is based on an ‘1 regularized logistic regression model that aggregates AML test ...

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Plos One : Med25 is a Mediator Component of Hnf4Α-driven Transcrip...

By: Francis C. Lynn

Description : Unique nuclear receptor Hepatocyte Nuclear Factor 4a (HNF4a) is an essential transcriptional regulator for early development and proper function of pancreatic ß-cells, and its mutations are monogenic causes of a dominant inherited form of diabetes referred to as Maturity Onset Diabetes of the Young 1 (MODY1). As a gene-specific transcription factor, HNF4a exerts its function through various molecular interactions, but its protein recruiting network has not ...

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Plos One : Cost-effectiveness Analysis of Option B+ for Hiv Preven...

By: Paula Braitstein

Description : In Malawi, Option B+ represents a favorable policy option from a cost-effectiveness perspective to prevent future infant infections, save mothers’ lives and reduce orphanhood. Although Option B+ would require more financial resources initially, it would save societal resources in the long-term and represents a strategic option to simplify and integrate HIV services into maternal, newborn and child health programmes.

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Plos One : the Sterile Insect Technique for Controlling Population...

By: Basil Brooke

Description : Reunion Island suffers from high densities of the chikungunya and dengue vector Aedes albopictus. The sterile insect technique (SIT) offers a promising strategy for mosquito-borne diseases prevention and control. For such a strategy to be effective, sterile males need to be competitive enough to fulfil their intended function by reducing wild mosquito populations in natura. We studied the effect of irradiation on sexual maturation and mating success of male...

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Plos One : Serum Microrna-122 Predicts Survival in Patients with L...

By: Justin L. Mott

Description : Serum miR-122 is a new independent marker for prediction of survival of patients with liver cirrhosis

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Plos One : Potassium and Ionic Strength Effects on the Conformatio...

By: Annalisa Pastore

Description : Many aldehyde dehydrogenases (ALDHs) have potential potassium-binding sites of as yet unknown structural or functional roles. To explore possible K+-specific effects, we performed comparative structural studies on the tetrameric betaine aldehyde dehydrogenase from Pseudomonas aeruginosa (PaBADH) and on the dimeric BADH from spinach (SoBADH), whose activities are K+-dependent and K+-independent, respectively, although both enzymes contain potassium-binding s...

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Plos One : Genome-wide Methylated Dna Immunoprecipitation Analysis...

By: Harpal Singh Randeva

Description : Polycystic ovary syndrome (PCOS) is a complex, heterogeneous disorder of uncertain etiology. Recent studies suggested that insulin resistance (IR) plays an important role in the development of PCOS. In the current study, we aimed to investigate the molecular mechanism of IR in PCOS. We employed genome-wide methylated DNA immunoprecipitation (MeDIP) analysis to characterize genes that are differentially methylated in PCOS patients vs. healthy controls. Besid...

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Plos One : the Impact of Full-length, Trimeric and Globular Adipon...

By: Rocio I Pereira

Description : Contribution of individual adiponectin isoforms to lipolysis regulation remains unknown. We investigated the impact of fulllength, trimeric and globular adiponectin isoforms on spontaneous lipolysis in subcutaneous abdominal (SCAAT) and visceral adipose tissues (VAT) of obese and non-obese subjects. Furthermore, we explored the role of AMPK (5’-AMPactivated protein kinase) in adiponectin-dependent lipolysis regulation and expression of adiponectin receptors...

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Plos One : the Novel Approach to Enhance Seed Security ; Dual Anti...

By: Randall P. Niedz

Description : Seed security is of prime importance for agriculture. To protect true seeds from being faked, more secure dual anticounterfeiting technologies for tobacco (Nicotiana tabacum L.) pelleted seed were developed in this paper. Fluorescein (FR), rhodamine B (RB), and magnetic powder (MP) were used as anti-counterfeiting labels. According to their different properties and the special seed pelleting process, four dual-labeling treatments were conducted for two toba...

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Plos One : Spatial and Temporal Patterns of Eastern Australia Subt...

By: Christopher Fulton

Description : Despite increases in the frequency and intensity of disturbances on coral reefs over the past few decades, the response of subtropical coral assemblages to climate change is poorly understood. To address this knowledge gap on Australian reefs and provide a baseline for future comparisons, we quantified spatial (10-100’s of kilometres) and temporal (decadal) patterns of benthic assemblages across a latitudinal gradient along the east Australian coastline (23...

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Plos One : Translating Evidence for Low Back Pain Management Into ...

By: Hamid Reza Baradaran

Description : Community pharmacies provided a feasible primary care portal for implementing evidence-based information. The associated improvement in work-related LBP-beliefs for consumers receiving the pamphlet suggests this simple intervention may be a useful component of care.

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Plos One : Computational Identification and Functional Predictions...

By: Liang-hu Qu

Description : Background : Computational analysis of cDNA sequences from multiple organisms suggests that a large portion of transcribed DNA does not code for a functional protein. In mammals, noncoding transcription is abundant, and often results in functional RNA molecules that do not appear to encode proteins. Many long noncoding RNAs (lncRNAs) appear to have epigenetic regulatory function in humans, including HOTAIR and XIST. While epigenetic gene regulation is clear...

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Plos One : Comparative Phylogeographic Analyses Illustrate the Com...

By: Michael Hofreiter

Description : Comparative phylogeography can elucidate the influence of historical events on current patterns of biodiversity and can identify patterns of co-vicariance among unrelated taxa that span the same geographic areas. Here we analyze temporal and spatial divergence patterns of cloud forest plant and animal species and relate them to the evolutionary history of naturally fragmented cloud forests–among the most threatened vegetation types in northern Mesoamerica. ...

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Plos One : Tolerance of an Expanding Subarctic Shrub, Betula Gland...

By: Anna-liisa Laine

Description : Densification of the shrub layer has been reported in many subarctic regions, raising questions about the implication for large herbivores and their resources. Shrubs can tolerate browsing and their level of tolerance could be affected by browsing and soils productivity, eventually modifying resource availability for the caribou. Our objective was to assess the compensatory growth potential of a subarctic shrub, Betula glandulosa Michx., in relation with ca...

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Plos One : a Novel Function for Snap29 Synaptosomal-associated Pro...

By: Wanjin Hong

Description : Mast cells play a critical role in the innate immune response to bacterial infection. They internalize and kill a variety of bacteria and process antigen for presentation to T cells via MHC molecules. Although mast cell phagocytosis appears to play a significant role during bacterial infection, little is known about the proteins involved in its regulation. In this study, we demonstrate that the SNARE protein SNAP29 is involved in mast cell phagocytosis. SNA...

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